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Wnt signaling activation

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation. Lei Ji et al., Genes & Development 2017, vol.31, 904–915
DOI: 10.1101/gad.300053.117

In this paper, authors demonstrate that an E3 ligase (IAH1/2 or SIAH) initiates a positive feedback loop to maintain activation of Wnt signaling. SIAH interacts with a VxP motif in Axin that is located within the GSK3-binding domain of the protein. Upon initial activation of Wnt signaling, Axin dissociates from the destruction complex, making it accessible to SIAH-mediated ubiquitination and degradation. This sets a feed-forward mechanism leading to sustained activation of the pathway.

jilei2017.txt · Last modified: 2017/06/01 02:00 by Bhagwati Gupta