Poole et al., PLoS Genetics 2011, volume 7, e1002109 (DOI: 10.1371/journal.pgen.1002109)
This paper reports first genome-wide screen for factors affecting a single neuronal fate in the nematode C. elegans.
A total of 245 genes were identified from a genome-wide RNAi screen that are involved in the development of a specific gustatory neuron ASEL. The genes include hlh-14 (bHLH proneural class) and COMPASS histone methyltransferase complex components. The screen was done in nre-1 lin-15b double mutant animals. These animals are more sensitive to neuronal RNAi compared to wild type (N2) and other mutants (e.g., rrf-3 alone and eri-1; lin-15b double).